Work

Constructing a limit model and developing an HPLC-MS/MS analytical method for measuring isothiazolinone migration from children's sports protectors into sweat

Year: 2025

Type: article

Abstract: ) exceeding 0.9990; the quantification limits of the method were 0.7-3.0 μg, which meets the requirements of the migration limits of the three isothiazolinones. The recoveries of the method are within the range of 87.2-114.8% with RSDs below 10%, and the RSDs of the intra-day precision and inter-day precision were less than 8%. The accuracy and precision of the method were between 87.2% and 114.8%, and the RSDs of intra-day and inter-day precision were below 8%. The accuracy and precision of the method meet the daily testing requirements. Different from the traditional isothiazolinone detection method, the method established in this study detects the migration amount of isothiazolinones rather than their total content in the samples, which is believed to be more scientific and efficient in protecting the skin health of infants and children.

Source: RSC Advances

DOI: 10.1039/d4ra08953g