Differences in Functional Lumen Imaging Probe ( FLIP ) Panometry Patterns Among Obese and Bariatric Surgery Patients With and Without Gastroesophageal Reflux Disease ( GERD )
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: During pre-bariatric surgery evaluation, we routinely perform objective testing for GERD (endoscopy, pH monitoring if no reflux esophagitis found) with high-resolution manometry (HRM) and functional lumen imaging probe (FLIP) to evaluate esophageal motility. In this study, we aimed to identify differences in FLIP metrics between obese patients with and without GERD. METHODS: We reviewed our clinical database of obese patients evaluated for bariatric surgery, including surgery-naïve patients and patients who had sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) that resulted in inadequate weight loss. We recorded GERD symptoms, HRM findings, and FLIP metrics (EGJ-diameter, distensibility index, and contractile response patterns). Patients with reflux esophagitis or acid exposure time (AET) > 6% were considered GERD+; those with AET ≤ 6% were deemed GERD. KEY RESULTS: We included 160 patients (mean age 50.2 ± 12.4 years; 79% women; 66 surgery-naïve) (29 GERD-, 37 GERD+), 70 SG (20 GERD-, 50 GERD+), 24 RYGB (16 GERD-, 8 GERD+). FLIP abnormalities were frequent, including reduced EGJ opening (REO) (12.1% surgery-naïve, 14.3% SG, 12.5% RYGB) and abnormal contractile response (59.1% surgery-naïve, 71.4% SG, 62.5% RYGB). FLIP differences were found between GERD+ and GERD- patients: REO (8.0% vs. 30.0%, p = 0.02) and BCR (2.0% vs. 15.0%, p = 0.02) were both less frequent in GERD+ than in GERD- SG patients. SRCR was more frequent in GERD- than in GERD+ surgery-naïve patients (31.0% vs. 5.4%, p = 0.01). CONCLUSIONS: While FLIP differences between GERD- and GERD+ patients exist, there were no FLIP metrics that clearly predicted GERD in obese patients either before or after bariatric surgery.
Source: Neurogastroenterology & Motility
DOI: 10.1111/nmo.70091
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4410904295