Work

Cryo-ablation management of atrial fibrillation in Fabry disease without agalsidase alpha: a case report

Year: 2025

Type: article

Abstract: gene, affecting multiple organs. Over 60% of patients experience heart-related issues, primarily arrhythmias. Unlike typical cases, these arrhythmias are complex and often do not respond well to standard antiarrhythmic drugs, sometimes worsening symptoms. This paper presents a case study of a FD patient with paroxysmal atrial fibrillation successfully treated using bilateral pulmonary vein cryoablation, resulting in positive outcomes. Additionally, we conducted molecular docking studies for the first time to assess the enzyme-substrate binding of E358del, confirming findings similar to laboratory experiments. Our findings underscore the potential role of artificial intelligence in better understanding FD, and aim to provide insights into managing arrhythmias associated with FD.

Source: Frontiers in Cardiovascular Medicine

DOI: 10.3389/fcvm.2025.1483283

Authors: Yuanzhu Li, Bi Huang, Suxin Luo

Institutions: The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing Medical University

Language: English

Topic: Atrial Fibrillation Management and Outcomes

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801