Year: 2025
Type: article
Study design: Observational Study
Abstract: Background Inflammation plays a crucial role in the onset and progression of epilepsy. However, there is limited information regarding the relationship between diet-related inflammation and epilepsy. This study aimed to investigate the association between dietary inflammatory index (DII) and epilepsy. Methods We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) 2013–2020. The DII scores were calculated and categorized into quartiles. Logistic regression was applied to assess the association between DII and epilepsy. Additionally, restricted cubic spline (RCS) analysis and subgroup analyses were performed. Results The study included a total of 10,761 participants. After adjusting for age, gender, race, body mass index (BMI), smoking status, alcohol consumption, stroke, diabetes, and hypertension, a significant positive association was observed between DII and epilepsy in multivariable logistic regression (quartile 4 vs. 1, OR = 2.66, 95% CI 1.66–4.28, p < 0.001). The RCS analysis further confirmed a positive linear relationship between increasing DII scores and epilepsy risk ( p for overall = 0.0007, p for nonlinear = 0.5128). Subgroup analyses showed a consistent association between DII and epilepsy across different subgroups. Conclusion Elevated DII scores are associated with the risk of epilepsy. To improve epilepsy prevention and management, attention to dietary inflammation regulation is essential.
Source: Frontiers in Neurology
Authors: Yike Zhu, Chuansen Lu
Institutions: Hainan General Hospital, Hainan Medical University
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4410905758