Micro/nanorobots in antimicrobial therapy: Addressing challenges of antibiotic resistance
Year: 2025
Type: article
Abstract: Antibiotic resistance has emerged as a critical global health challenge, particularly when bacteria form biofilms that render conventional antimicrobial treatments markedly less effective. Bacteria residing within biofilm exhibit increased resistance to antimicrobial agents and host immune defenses, complicating treatment and contributing to recurrent infections. Antimicrobial micro- and nanorobots (MNRs) have garnered significant attention as a promising strategy to combat drug-resistant bacteria and biofilms, owing to their exceptional motility, precise targeting, and improved penetration capabilities. Despite their potential, challenges related to biocompatibility, imaging integration, and clinical translation remain unresolved. This review summarizes the latest developments in the therapy of micro/nanorobots for antimicrobial therapy, emphasizing innovative strategies for bacterial eradication and biofilm disruption while addressing the technical hurdles and exploring future research directions.
Source: Materials Today Bio
Authors: Xutong Chen, Yong Li, Chunhua Wang, Zhiqiang Chen, Zhijie Xu, Fada Xia, Yuanliang Yan, Ming Gao
Institutions: Chinese Academy of Sciences, Research Center for Eco-Environmental Sciences, University of Chinese Academy of Sciences, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Hunan Children's Hospital, Tokushima University, Central South University, Xiangya Hospital Central South University
Language: English
Topic: Micro and Nano Robotics
Subfield: Condensed Matter Physics
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,400
Awards: G3889201997, G7806174060
OpenAlex ID: W4410909444