Bioorthogonal probes for L-form conversion visualization and insights into antimicrobial resistance
Year: 2025
Type: article
Abstract: , resulting in a 4.9-fold increase in fluorescence intensity. This platform exhibited excellent labeling of peptidoglycan in both Gram-positive and Gram-negative bacteria (signal-to-noise ratio: 15 to 305), effectively capturing the transition from N-form to L-form. Furthermore, we investigated the impact of 14 kinds of antibiotics on L-form conversion and found 13 of them induced CWDB. Besides, we explored the relationship between L-form conversion and AMR. This research enhances our understanding of bacterial adaptations and resistance mechanisms, paving the way for innovative strategies to combat drug-resistant infections.
Source: Chemical Science
DOI: 10.1039/d5sc01586c
Authors: Yunzhe Tao, Yongwei Feng, Yu Peng, Xiang Wang, Xiangchuan Meng, Youjun Xu, Xiaowan Han, Qingyang Zhang, Hai-Yu Hu
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4410918822