A Case of Severe Anaphylaxis Following Iohexol Administration
Year: 2025
Type: article
Study design: Case Report
Abstract: Iohexol is a typical iodinated radiocontrast medium that is widely used in imaging examinations. The molecular structure of iohexol, which contains iodine, can trigger a complex immune response, leading to anaphylactic reactions that may manifest as cardiovascular instability, respiratory distress, or even cardiac arrest. Timely identification and intervention are crucial to prevent long-term consequences. Therefore, information on clinical features and management strategies for iohexol-related anaphylaxis is important. Recent reports suggested that the overall incidence of ADRs and serious ADRs with non-ionic iodinated contrast media was about 1 % and 0.01 %, respectively. Here we report a case of a 55-year-old female with a known history of systemic hypertension and hyperthyroidism who presented to the radiology department for a CT scan of the neck with iohexol for further evaluation of her goitre, who developed a sudden onset of drowsiness with multiple episodes of vomiting and breathlessness following iohexol administration.
Authors: Navya Benoy, Telma Titto, Akash Jose, George Thayil
Institution: Lourdes Hospital
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4410920104