Work

Preparation, characterization, and application of a valine-malonic acid based-DES as a potent catalyst for the green synthesis of thiazolopyrimidines

Year: 2025

Type: article

Abstract: Based on the eutectic point phase diagram, a novel natural deep eutectic solvent (VAL/MAL-DES) was prepared by a mixture of one mole of valine (VAL) and one mole of malonic acid (MAL), and characterized by the eutectic points, FT-IR, 1 HNMR, TGA/DTA and densitometer techniques. Then, it was used as a novel and capable catalyst for the green synthesis of thiazolo[3,2- a ]pyrimidines via a one-pot four-component condensation reaction of 4-hydroxycoumarin, 2-amino-6-methylbenzothiazole, morpholine, and aldehydes at 80 °C with high yield and short reaction time.

Source: Scientific Reports

DOI: 10.1038/s41598-025-03630-3

Authors: Nastaran Dehnokhalaji, Davood Habibi, Arezo Monem, Afagh Ranjbaran

Institution: Bu-Ali Sina University

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,690

OpenAlex ID: W4410920190