The LIDPAD Mouse Model Captures the Multisystem Interactions and Extrahepatic Complications in MASLD (Adv. Sci. 35/2024)
Year: 2024
Type: article
Abstract: Metabolic Dysfunction-Associated Steatotic Liver Disease The LIDPAD model, a single-mouse metabolic dysfunction-associated steatotic liver disease (MASLD) model using thermoneutral housing and refined diet, replicates key human MASLD features, such as metabolic syndrome, gut dysbiosis, multiorgan dysfunction, and neurobehavioral anomalies in a short period. Hepatic transcriptomic-guided staging confirms its close human relevancy, making it an invaluable tools for advancing translational liver disease research. More details can be found in article number 2404326 by Nguan Soon Tan, Walter Wahli, and co-workers.
Source: Advanced Science
Authors: Zun Siong Low, Damien Chua, Hong Sheng Cheng, Rachel Tee, Wei Ren Tan, Christopher Ball, Norliza Binte Esmail Sahib, Ser Sue Ng, Jing Qu, Yingzi Liu, Haiyu Hong, Chaonong Cai, Nandini Chilagondanahalli Lakshmi Rao, Aileen Wee, Mark Dhinesh Muthiah, Zoë Bichler, Barbara Mickelson, Mei Suen Kong, Vanessa Shiyun Tay, Zhuang Yan, Jiapeng Chen, Aik Seng Ng, Yun Sheng Yip, Marcus Ivan Gerard Vos, Nicole Ashley Tan, Dao Liang Lim, Debbie Xiu En Lim, Manesh Chittezhath, Jadegoud Yaligar, Sanjay Kumar Verma, Harish Poptani, Xue Li Guan, Sambasivam Sendhil Velan, Yusuf Ali, Liang Li, Nguan Soon Tan, Walter Wahli
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $6,120
OpenAlex ID: W4410922193