Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To investigate the clinical features and risk factors of bloodstream infections in the older adults. METHODS: This was a prospective cohort multicenter study. According to the inclusion and exclusion criteria, older adults with suspected bloodstream infections from December 2020 to June 2023 were included in the analysis of the clinical features of older adults bloodstream infections. RESULTS: A total of 338 older adultswith suspected bloodstream infections were included, of which 141 were diagnosed with bloodstream infections. The proportion of gram-negative bacteria (47.5%) was close to that of gram-positive bacteria (46.1%), while the proportion of gram-negative bacteria was slightly higher.The common clinical manifestations of bloodstream infection were fever (75.2%), decreased level of consciousness (24.8%), chills (14.2%), shock (12.1%), etc.Multivariate regression analysis showed high procalcitonin levels at admission (OR = 2.008, 95%CI 1.258-3.206, P = 0.003) and heart rate > 90 beats/min (OR = 2.104, 95%CI 1.302-3.400). P = 0.002), arterial partial blood pressure of carbon dioxide < 32 mmHg (OR = 1.922, 95%CI 1.025-3.601, P = 0.042), and coronary heart disease (OR = 1.909, 95%CI 1.134-3.213), P = 0.015) were independent risk factors for bloodstream infection in the older adults. CONCLUSION: The proportion of gram-negative and gram-positive bacteria in bloodstream infections in older adults was similar. The common clinical features of bloodstream infection in the older adults are fever and a decreased level of consciousness, and there was no significant difference in systemic clinical manifestations between bloodstream infection and non-bloodstream infection. High procalcitonin (PCT) level, heart rate > 90 beats/min, arterial partial pressure of carbon dioxide (PaCO2) < 32 mmHg, and underlying coronary heart disease were independent risk factors for bloodstream infection in older adults.
Source: BMC Geriatrics
Authors: Mengxi Ding, Yachan Ning, Lipo Song, Xueyuan Yu, Bin Yan, Peijuan Li, Wei Tian, Rongrong Zhang, Wei Chen, Jie Zhen, Fang Lin, Xun Huang, Shuangling Li, Qiao Qin, Zhihong Sun, Yingfeng Wu, Chunmei Wang
Institutions: Capital Medical University, Xuan Wu Hospital of the Capital Medical University, Sichuan University, West China Hospital of Sichuan University, Beijing Jishuitan Hospital, University of Science and Technology of China, Beijing Shijitan Hospital, Beijing Friendship Hospital, Xiangya Hospital Central South University, Peking University First Hospital, Chinese PLA General Hospital, Chinese People's Liberation Army, Beijing Luhe Hospital Affiliated to Capital Medical University
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,190
Award: G6529863924
OpenAlex ID: W4410922678