Neural Tissue‐Like, not Supraphysiological, Electrical Conductivity Stimulates Neuronal Lineage Specification through Calcium Signaling and Epigenetic Modification (Adv. Sci. 35/2024)
Year: 2024
Type: article
Abstract: Conductivity-Dependent Neuronal Specification In article number 2400586, Hae-Won Kim, Jung-Hwan Lee, and co-workers show that neural-tissue-like, low conductivity (0.02–0.1 S m–1) promotes neuronal differentiation via balanced calcium signaling and epigenetic changes, while supraphysiological, high conductivity (3.2 S m–1) causes apoptosis. This work reveals optimal conductivity's crucial role in neural interface design for tissue engineering and regenerative medicine.
Source: Advanced Science
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,120
OpenAlex ID: W4410922822