Year: 2024
Type: article
Study design: Systematic Review
Abstract: This review investigates the complex role of the gut microbiome in modulating treatment resistance in colorectal cancer (CRC), examining mechanisms that influence therapeutic outcomes across chemotherapy, immunotherapy, and targeted therapies. Through a systematic search of databases, including PubMed, Scopus, Embase, Web of Science, SciELO, and gray literature from Google Scholar, we identified relevant studies addressing microbial interactions with cancer treatments. Key insights reveal how specific microbial species, such as Fusobacterium nucleatum, impact chemotherapy efficacy by altering drug metabolism and promoting immune evasion.
Author: Irami Araújo-Filho
Institution: Universidade Potiguar
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4410923017