Work

Rapidly Progressive Joint Destruction in Idiopathic Multicentric Castleman’s Disease: A Case Report

Year: 2025

Type: article

Abstract: Castleman's disease (CD) is a group of lymphoproliferative disorders characterized by common morphological features on lymph node biopsy, with idiopathic multicentric Castleman's disease (iMCD) being a notable subtype. Here, we report a 69-year-old Japanese iMCD patient complicated by rapidly progressive joint destruction. Her joint destruction progressed rapidly around the time of her iMCD diagnosis, and she underwent right total hip arthroplasty (THA). Synovial tissue revealed rheumatoid arthritis (RA)-like synovitis. Joint destruction continued to progress even after tocilizumab (TCZ) was initiated for iMCD. Before long, she underwent left THA. Joint destruction due to cytokines other than interleukin-6 (IL-6), or other inflammatory pathologies, was suspected. Mechanistic target of rapamycin (mTOR) activation in iMCD may promote synovitis and joint erosion by regulating immune cell function and osteoclast differentiation. Although there are common pathological mechanisms between iMCD and destructive synovitis (RA-like synovitis), a case of rapidly progressive bone destruction has not been previously reported. Therefore, we report a unique case of iMCD complicated by destructive synovitis (RA-like synovitis) to contribute to the understanding of these overlapping disease mechanisms and potential therapeutic strategies.

Source: Cureus

DOI: 10.7759/cureus.85108

Authors: Haruki Matsumoto, Naoki Matsuoka, Kazuhiro Tasaki, Noriyoshi Sato, Masahito Kuroda, Masayuki Miyata

Institutions: Fukushima Medical University, Fukushima Red Cross Hospital, Fukushima Rosai Hospital

Language: English

Topic: Viral-associated cancers and disorders

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4410925164