Effect of a nature-derived combination of Ananas comosus and Bambusa bambos (L.) in hyperlipidemic experimental animals
Year: 2025
Type: article
Abstract: Hyperlipidemia is an independent modifiable risk factor of cardiovascular diseases which remains the leading cause of disease burden for healthcare systems worldwide. Traditional medicine formulas have a long history of use in Asia for hyperlipidemia treatment. This study aimed to evaluate the potential efficacy of a herbal combination of Ananas comosus and Bambusa bambos (L.), named "Cao dua tre Lao nha que" (CDT), on hyperlipidemic animal models of two pathways. In poloxamer-407 (P-407)-induced model, mice were pre-treated with CDT before intraperitoneal injection of P-407; in the dietary model, rats were orally administered a cholesterol mixture and CDT for 4 consecutive weeks. Results indicated that CDT (0.6 and 1.2 g/kg b.w.) significantly reduced total cholesterol (TC) (from 4.11±0.95 to 3.05±0.60 and 2.93±0.67 mmol/L, respectively) and triglycerides (TG) (from 1.40±0.27 to 1.02±0.20 and 1.13±0.31 mmol/L) in the dietary model; in P-407-induced model, CDT significantly reduced TG (from 5.8±1.52 to 4.84±0.95 and 4.76±0.55 mmol/L, respectively) and TC (from 6.09±1.36 to 4.42±1.14 and 4.53±1.15 mmol/L) compared to untreated hyperlipidemic controls. CDT improved the serum lactate dehydrogenase (LDH) levels (from 748.50±120.79 to 475.30±109.53 and 534.30±127.74 U/L) and ameliorated the elevated serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the cholesterol-induced hyperlipidemic rats, suggesting hepatoprotective effects. No dose-dependent relationship was observed. In conclusion, CDT demonstrated efficacy in hyperlipidemia treatment by improving lipid profiles and offering hepatoprotection, highlighting its potential to serve as a promising adjunctive therapy for hyperlipidemia and related disorders.
Authors: Van Anh T. Pham, Phong Pham, Tung Tran, Hien Dang, Quang Trinh, Duong Dau
Institution: Hanoi Medical University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4410929442