Work

New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain

Year: 2025

Type: review

Abstract: The rodent olfactory system is unique in harboring two distinct postnatal neurogenic niches, the olfactory epithelium and the subventricular zone. This results in the ongoing generation of both olfactory sensory neurons (OSNs), which provide odor input to the brain, and multiple molecularly distinct populations of GABAergic interneurons that modulate both input to and output from the olfactory bulb, continuing throughout life for some neuronal types. Here, we review the roles played by these postnatally generated neurons in olfactory processing, plasticity and regeneration. We identify specific roles for individual types of postnatally generated neurons, as well as identifying overarching principles that span multiple neuronal types.

Source: Brain Sciences

DOI: 10.3390/brainsci15060597

Authors: Jordan D. Gregory, Tenzin Kunkhyen, Sean C. Sweat, Jane S. Huang, Taryn R. Brechbill, Claire E. J. Cheetham

Institution: University of Pittsburgh

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,654

Funders: National Institutes of Health, National Institute on Deafness and Other Communication Disorders, National Institute of General Medical Sciences