Work

IgA nephropathy: Update on pathogenesis and treatment

Year: 2025

Type: review

Abstract: The pathogenesis of immunoglobulin (Ig) A nephropathy is described through a "4-hit" model involving production of galactose-deficient IgA, production of autoantibodies to galactose-deficient IgA, and subsequent deposition of immune complexes in the kidney glomerulus. Diagnosis remains dependent on a kidney biopsy, often after hematuria or proteinuria is detected on urinalysis. The cornerstone of therapy still involves renin-angiotensin-aldosterone system inhibitors or corticosteroids; however, new therapies targeting key aspects of the pathogenesis of IgA nephropathy are being introduced.

Source: Cleveland Clinic Journal of Medicine

DOI: 10.3949/ccjm.92a.24105

Authors: Seshma Ramsawak, Scott Cohen, Andrea Linares, Corey Cavanaugh

Institutions: Cleveland Clinic, Cleveland Clinic Florida, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University

Language: English

Topic: Renal Diseases and Glomerulopathies

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Gilead Sciences