Recent Advances in the Synthesis and Structural Elucidation of Tetrasubstituted Pyrroles Under Superbasic Condition
Year: 2025
Type: article
Abstract: Pyrrole derivatives are widely recognized for their presence in biologically active natural products, pharmaceuticals, and advanced functional materials.Given their significant role in systems such as heme, chlorophyll, and vitamin B₁₂, the development of efficient synthetic approaches to functionalized pyrroles remains a crucial objective in organic chemistry.In this study, we investigated a three-step synthesis of β-substituted pyrrole derivatives based on aromatic-substituted 1,3-dicarbonyl compounds and 2,3-dibromoprop-1-ene.New 2phenyl tetra substituted pyrroles were synthesized in a superbasic medium comprising t-BuOK/DMSO in t-BuOH.The structure of new synthesized compounds were confirmed by 1 H and 13 C NMR spectroscopy.
Author: Ayten Safarova, Abel Maharramov, Khammed Asadov, Farid Naghiyev, Elnur Huseynov
Institution: Baku State University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4410957753