Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Polycystic Ovary Syndrome (PCOS) is a reproductive, metabolic, and psychiatric endocrine disorder. The increasing evidence points toward the firm relationship between PCOS and anxiety but does not identify the underlying relationships.Aim: To investigate the relationship between PCOS and anxiety, evaluating potential causative factors including hormonal deregulation, metabolic imbalance, and markers of inflammation.Methods: The research involved 250 women participants were recruited, 150 with PCOS (experimental group) and 100 controls. Anxiety was measured by a validated questionnaire for anxiety. Hormonal and metabolic variables, such as insulin resistance (HOMA-IR), testosterone, BMI, and C-reactive protein (CRP), were measured and correlated with anxiety scores. Statistical tests were utilized to establish significant differences and correlations.Results: The evidence favours hormonal dysregulation, metabolic derangement, and systemic inflammation as the etiopathogenic factors in anxiety in PCOS patients. Hyperandrogenism and insulin resistance are associated with neuro-chemical alterations in mood control, while systemic inflammation is associated with increased psychological distress. These physiological changes could be the intrinsic factors for increased incidence of anxiety in PCOS.Conclusion: The research identifies a high level of correlation between PCOS and anxiety, with insulin resistance, elevated testosterone, BMI, and inflammation being significant contributory factors. Intervention in these variables is helpful in improving mental health outcomes among PCOS patients. Longitudinal trends and possible therapeutic options for decreasing anxiety in this group should be the focus of future studies.
DOI: 10.56294/hl2025617
Authors: Nidhi Nidhi, Prashant Modi, Shivam Khurana, Sukhman Ghumman, Mansi Mishra, Bathala Balaji
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4410962981