Synthetic approaches to bis-adenosine derivatives as potential bisubstrates of RNA methyltransferases
Year: 2025
Type: article
Abstract: triazole- and amide-based connectors. Cellular assays demonstrate that these compounds were not cytotoxic at 10 μM on SW620 and MCF-7 human cancer cell lines. Notably, one conjugate significantly affected several mRNA methylation processes in colorectal SW620 cells at this concentration. Furthermore, four compounds inhibited sphere formation in both cancer cell lines, underscoring their potential as tools to modulate RNA methylation in oncogenic contexts and guide the design of new therapeutic agents.
Source: Organic & Biomolecular Chemistry
DOI: 10.1039/d5ob00758e
Institutions: Centre National de la Recherche Scientifique, Université Paris Cité, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Inserm, Centre Hospitalier Universitaire de Montpellier, Institute for Regenerative Medicine & Biotherapy, Institut de Recherche en Cancérologie de Montpellier
Language: English
Topic: RNA modifications and cancer
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4410965886