Figure S3 from The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect
Year: 2025
Type: other
Abstract: Figure S3A showing results of FRET assays to demonstrate oligomerization of R248Q and WT. Figure S3B-C underlining the dimer-of dimer topology as tetramers are largely formed upon dimerization of homodimers. Figure 3D-E demonstrating that WT p53 functionality depends on oligomerization and further, that the dependency of the DNE relies on the oligomerization capability of R248Q.
Authors: Nancy Klemm, Roman R. Schimmer, Nils K. Konrad, Flavian Thelen, Jonas Fullin, Ebru Topçu, Christian Koch, Milena Treacy, Matthew Joseph Leventhal, Marco M. Bühler, Veronika Lysenko, Alexandre P.A. Theocharides, Kari J. Kurppa, Stefan Balabanov, Tuncay Baubec, Andrei V. Krivtsov, Peter G. Miller, Scott A. Armstrong, Benjamin L. Ebert, Markus G. Manz, Cesar Nombela-Arrieta, Steffen Boettcher
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4410970899