Assessing the Role of Inflammatory Markers in Predicting Central Lymph Node Metastasis in Papillary Thyroid Carcinoma.
Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction: The current study sought to assess the predictive value of inflammatory markers, namely the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR), in relation to central lymph node metastasis (CLNM) in patients with papillary thyroid carcinoma (PTC). Materials and Methods: A total of 79 participants with confirmed PTC diagnosis following surgery were included in the study. Demographic data, clinical characteristics, and laboratory variables were collected. CLNM was evaluated based on pathological findings. NLR and PLR were calculated to assess their associations with clinicopathological features and metastasis. Results: =0.011). Conclusion: This study demonstrates significant associations between clinicopathological features and CLNM in PTC. Male gender, larger tumor size, and multifocality correlated with higher CLNM rates. While inflammatory markers such as NLR and PLR did not show significant differences, PLR's positive correlation with age in CLNM patients suggests potential prognostic value, warranting further investigation.
Source: PubMed
Authors: Ebrahim Farashi, Sajjad Ranjbar, Sahand Eslami, Nikzad Shahidi, Seyed Ziaeddin Rasihashemi
Institution: Tabriz University of Medical Sciences
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4410975715