Work

Antibacterial gold nanoclusters combined with meropenem for the treatment of sepsis by alleviating the cytokine storm

Year: 2025

Type: article

Abstract: a one-pot method. The therapeutic efficacy of AuDAMP was systematically evaluated in two sepsis mouse models: the cecum ligation and puncture (CLP) model and the lipopolysaccharide (LPS)-induced sepsis-associated acute lung injury model. Remarkably, AuDAMP demonstrated potent anti-septic effects through antimicrobial activity and attenuation of the cytokine storm. Furthermore, AuDAMP exhibited synergistic therapeutic effects when combined with meropenem, suggesting great potential as a novel therapeutic strategy for sepsis management.

Source: Nanoscale Advances

DOI: 10.1039/d5na00234f