Work

Comprehensive biomedicine assessment of Apteranthes tuberculata extracts: Phytochemical analysis and multifaceted pharmacological evaluation in animal models

Year: 2025

Type: article

Abstract: Background: (EEAT) on various physiological parameters in mice. Objective: The research aimed to quantify flavonoid and phenol contents across different extraction methods, with a focus on the superior efficacy of the ethanolic extract. Methods: assays were conducted to assess the antioxidant activity of EEAT, revealing dose-dependent effects and significant inhibition percentages. Results: EEAT exhibited notable analgesic effects in the writhing response test, particularly at 200 mg/kg, indicating its potential as a natural analgesic. Additionally, its anti-inflammatory effects were complex and dose-dependent in a carrageenan-induced paw edema model. The extract also showed significant changes in body temperature regulation following Brewer's yeast-induced fever, revealing a distinct pattern of initial hypothermia followed by gradual re-elevation. Furthermore, EEAT demonstrated regulatory effects on gastrointestinal motility, with higher doses enhancing intestinal transit in charcoal meal tests. Conclusion: This study highlights the pharmacological potential of EEAT as a natural therapeutic agent for antioxidant, analgesic, anti-inflammatory, and gastrointestinal regulation, warranting further investigation into its mechanisms of action and therapeutic applications.

Source: Open Medicine

DOI: 10.1515/med-2024-1092

Authors: Sajida Afzal, Siraj Khan, Muhammad Imam Ammarullah

Institutions: Shenzhen University, Qarshi University, Diponegoro University, University of Liberia

Language: English

Topic: Medicinal Plant Research

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,373