Work

A New Route for the Synthesis of Thiazole‐Fused Pyrimidinone Derivatives via Regioselective Intramolecular Mitsunobu Reaction

Year: 2025

Type: article

Abstract: ABSTRACT This study presents a new route for synthesizing thiazole‐fused pyrimidinone derivatives through a regioselective intramolecular Mitsunobu reaction. Previous methods used simultaneous bis‐alkylation or 2‐aminothiazoline as the uronium derivative in ring closure to form the desired products. However, these methodologies can give a mixture of regioisomers, which was not observed in our results. The developed method showed good to moderate chemical yields and can be applied to synthesizing biologically active compounds.

Source: Journal of Heterocyclic Chemistry

DOI: 10.1002/jhet.4956

Authors: Ilária M. S. Lins, Sidney G. D. Feitosa, Janaína V. dos Anjos

Institution: Universidade Federal de Pernambuco

Language: English

Topic: Synthesis of heterocyclic compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,400

Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco, Universidade Federal de Pernambuco