Figure S1-S10 from Functional Reprogramming of Neutrophils within the Brain Tumor Microenvironment by Hypoxia-Driven Histone Lactylation
Year: 2025
Type: other
Abstract: Supplementary Figure 1. GBM-infiltrating Neutrophils are immunosuppressive cells. Supplementary Figure 2. CD71 identifies a cluster of hypoxic and glycolytic Neutrophils. Supplementary Figure 3. CD71+ Neutrophils are long-lived and mature cells that are found in the hypoxic-glycolytic niches of brain tumors. Supplementary Figure 4. CD71+ Neutrophils are immunosuppressive cells within the GBM TME. Supplementary Figure 5. CD71 expression and the immunosuppressive ability cannot be induced in CD71− Neutrophils. Supplementary Figure 6. Hypoxic CD71+ Neutrophils are long-lived cells but CD71 is not required for their immunosuppressive ability. Supplementary Figure 7. Hypoxia boosts the glycolytic metabolism of CD71+ Neutrophils. Supplementary Figure 8. Extracellular lactate and histone acetylation are not involved in the regulation of the immunosuppressive ability of hypoxic CD71+ Neutrophils. Supplementary Figure 9. Isosafrole specifically inhibits the immunosuppressive ability of hypoxic CD71+ Neutrophils. Supplementary Figure 10. Human CD71+ neutrophils are glycolytic and immunosuppressive cells.
Authors: Alessio Ugolini, Alessandra De Leo, Xiaoqing Yu, Fabio Scirocchi, Xiaoxian Liu, Barbara Peixoto, Delia Scocozza, Angelica Pace, Michela Perego, Alessandro Gardini, Luca D’Angelo, James K.C. Liu, Arnold B. Etame, Aurelia Rughetti, Marianna Nuti, Antonio Santoro, Michael A. Vogelbaum, Jose R. Conejo-Garcia, Paulo C. Rodriguez, Filippo Veglia
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4411004153