Supplemental Figure S3 from Exploring STEAP1 Expression in Prostate Cancer Cells in Response to Androgen Deprivation and in Small Extracellular Vesicles
Year: 2025
Type: supplementary-materials
Abstract: Correlation of STEAP1 expression with AR and AR target genes in primary and metastatic PCa cohorts Gene expression correlations of STEAP1, AR and canonical AR target genes KLK2, KLK3, KLK15, NKX3-1 and TMPRSS2. mRNA expression from Z-scores quantified by RNA Seq V2 RSEM for primary and FPKM for metastatic. (A) Primary Prostate Adenocarcinoma (TCGA Firehose Legacy) and (B) Metastatic Prostate Adenocarcinoma (SU2C/PCF Dream Team, 2019). (C) RNA-sequencing values from 210 mCRPC patient biopsies. Correlations between Z-scores of AR activity (top row) and KLK3 (bottom row) with STEAP1 and STEAP2. AR activity was measured as the mean Z-score of 7 AR target genes.
Authors: Candice L. Bizzaro, Camila A. Bach, Ricardo A. Santos, Cecilia E. Verrillo, Nicole M. Naranjo, Ishan Chaudhari, Francis J. Picone, Waleed Iqbal, Ada G. Blidner, Gabriel A. Rabinovich, Alessandro Fatatis, Justine Jacobi, David W. Goodrich, Kevin K. Zarrabi, Wm. Kevin Kelly, Matthew J. Schiewer, Lucia R. Languino
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4411005288