Gut-heart-brain Axis: Understanding the Interplay in Patients With Congenital Heart Disease
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Congenital Heart Disease (CHD) is a significant health concern globally, with a notable prevalence in India. The interconnections between gut health, heart function, and brain activity—the Gut-Heart-Brain Axis—may play a critical role in the morbidity and management of CHD. However, the interplay of these systems has not been extensively studied within the Indian demographic. Methods: In a cross-sectional study of 100 Indian patients with CHD, we assessed the Gut Health Score (GHS), Heart Function Score (HFS), and Brain Function Score (BFS) to evaluate their individual and interactive contributions to the Overall Health Score (OHS). Statistical analyses included ANOVA, correlation coefficients, and multiple regression. Results: Each health score significantly contributed to the OHS, indicating their individual importance in CHD outcomes. Notably, a significant interaction between GHS and HFS suggested a synergistic effect on patient health. No significant direct interaction between GHS and BFS or a three-way interaction among the health scores was observed. Conclusions: Our findings suggest the Gut-Heart-Brain Axis's influence on CHD outcomes in the Indian population, with significant implications for integrated patient care. The study advocates for a multidisciplinary approach to CHD management, considering the patient's holistic health status. Implications: This study provides a foundation for future research into the Gut-Heart-Brain Axis and supports the integration of multidisciplinary strategies in clinical settings to improve the management of CHD in India.
Authors: Anshul Mangal, Ashok Solanki, Manoj Yadav
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4411005850