Work

From Chromosomal Aberrations to Transcriptome Analysis: Four Decades of Research in Bivalve Genotoxicity

Year: 2025

Type: article

Abstract: Over the past four decades, bivalves have become sentinel organisms in genotoxicity research due to their ecological relevance and sensitivity to environmental contaminants. This integrative review critically examines the evolution of genotoxicity in bivalves, from early cytogenetic assays to advanced transcriptomic approaches. It highlights key methodological developments, geographical research trends, and the recent integration of multi-endpoint analyses for a more robust, consistent environmental risk assessment. By synthesizing data from four decades of research, we provide a comprehensive overview of current knowledge while also critically identifying persistent challenges and suggesting directions for future research to allow better evaluation and mitigation of the genetic impacts of marine pollution.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms26115389

Authors: Zenaba Khatir, Alexandra Leitão

Institutions: Centre National de la Recherche Scientifique, Ifremer, Laboratoire des Sciences de l'Environnement Marin, Institut de Recherche pour le Développement, Qatar University

Language: English

Topic: Environmental Toxicology and Ecotoxicology

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Life below water

Open Access status: gold

Estimated APC paid: $3,499