Year: 2025
Type: article
Abstract: Background: Osteoporosis is a systemic disease of the skeletal system, characterized by low mineral density and the deterioration of the micro-architecture of the bone tissue, with a consequent increase in bone fragility which has a significance for dentists and TMJ specialists as well. Aim: The purpose of this study was to analyze the importance of the Receptor Activator of Nuclear (RANK) ligand-osteoprotegerin system in bone metabolism and evaluate what may be predicting factors of early diagnosis while taking into consideration the impact of gender. Methods: In this study diagnostic strategies are proposed in situations predisposing to osteoporosis. The RANK ligand-osteoprotegerin system could be an excellent tool for prevention. Conclusion: Prevention remains the best strategy in avoiding the development of this disorder which can be disabling but also it could be leading to lethal consequences if neglected. The use of specific screenings such as those using RANK-ligand osteoprotegerin can be useful to reduce the onset of the disease. Furthermore, due to its significantly different impact in males vs. females.
Authors: Sabina Saccomanno, Francesco Bove, Francesca Greco, Giorgio Bove, Elisabetta Guercio, Gabriele Bove, Franklin Garcia-Godoy, Daniela Prosperi
Language: English
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4411030034