Meta-adaptive biomaterials: multiscale, spatiotemporal organization and actuation in engineered tissues
Year: 2025
Type: review
Abstract: Organized cell architecture and dynamic forces are key for (re)creating native-like tissue function (e.g., contractile soft tissues). However, few studies have explored the combined effects of material-guided 3D cell organization with mechanical stimulation. Herein we underscore the importance of converging material-driven guidance of cell organization with stimulus-responsive actuation for multiscale biomaterial design, outlining strategies to engineer such biomaterials. Given the state-of-the-art biomaterials for multiscale spatiotemporally controlled organization and actuation, we propose a synergistic approach ('meta-adaptive biomaterials') that unlocks complexity in engineered biomaterials, harnessing adaptive feedback pathways arising from cell-material interactions. These can be designed similarly to cell-extracellular matrix (ECM) interactions to reinforce user-specified behaviors and yield functionalities that resemble or surpass native tissues, expanding possibilities in tissue engineering, in vitro models, and biohybrid robotics.
Source: Trends in biotechnology
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $7,030
Awards: ICVS/3B’s - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos, ICVS/3B’s - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos, G3462379422, BioMIN –Biofabrication of Living Tendon Grafts with Growth Factor Sequestering Bioinks based on Molecularly Imprinted Nanoparticles, G3891562754, Plataforma wireless de atuadores abióticos para estudar a mecanobiologia dos receptores PIEZO, G6200009352, G6704445320, G6997658380, G7268105515, G7274947606, G7765502602, G8044159345
OpenAlex ID: W4411043376