Work

Carbonyl-bridged trifluoromethyl pyridine derivatives for pest control and mechanistic investigations

Year: 2025

Type: article

Abstract: ABSTRACT Trifluoromethyl pyridine ( TFMP ) motif is commonly discovered in structures of active pharmaceuticals. Flonicamid, characterized by the TFMP moiety, is well known as a prodrug in the knockdown of pests. The azobenzene-modified TFMP derivatives have been previously reported with excellent insecticidal activities. Herein, twenty-one TFMP derivatives were designed by the introduction of carbonyl-bridged aryl groups and synthesized via a one-step synthesis using Flonicamid as the starting material. The structure-activity relationships of these compounds were well analyzed and discussed. A molecular docking study and calcium ion concentration analysis indicated that compound FC13 could have interacted with the nicotinamidase enzyme, which further influenced the Ca 2+ influx.

Source: Advanced Agrochem

DOI: 10.1016/j.aac.2025.05.003