Work

Total Syntheses of Stereoisomeric Congeners of Rufomycin Natural Products Having Anti-Mycobacterial Activity

Year: 2025

Type: article

Abstract: Syntheses of bioactive rufomycin natural product congeners that differ in stereochemistry at a conserved methyl-substituted amino-hydroxy-piperidone (Ahp) moiety have been achieved for the first time. In addition to gaining new insights into the formation and conformation of the Ahp stereoisomers, we were intrigued to find that theirs reduction improves rufomycin bioactivity significantly.

Source: Organic Letters

DOI: 10.1021/acs.orglett.5c01525

Authors: Fan Fei, Shichun Lun, Alexander Pacheco, William R. Bishai, Jason K. Sello

Institutions: University of California, San Francisco, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: University of California, San Francisco, National Institute of Allergy and Infectious Diseases