BP and Kidney Disease Progression in Advanced CKD
Year: 2025
Type: article
Abstract: Key Points Higher BP was associated with a higher risk of kidney disease progression in patients with CKD G3b–G5. A stronger association observed with time-updated BP emphasizes the importance of consistently maintaining optimal BP over time. Further validation through well-designed clinical trials is warranted to determine optimal BP in patients with CKD. Background BP control is important in the management of CKD. However, in patients with advanced CKD, the benefits of BP control in delaying the progression of CKD remain uncertain. Methods We analyzed 2939 participants with CKD G3b–G5 (eGFR <45 ml/min per 1.73 m 2 ) without KRT from the Chronic Renal Insufficiency Cohort study and the KoreaN Cohort Study for Outcome in Patients with CKD (phase 1). The main predictors were baseline and time-updated systolic BP (SBP) and diastolic BP. The primary outcome was a composite kidney outcome of ≥50% decline in eGFR from baseline measurement or the initiation of KRT. In the analyses, multivariate cause-specific hazards models and marginal structural models were fitted for baseline and time-updated BPs, respectively. Results During 17755 person-years of follow-up (median, 4.7 years), the composite outcome occurred in 1627 (55%) participants. Compared with baseline SBP <120 mm Hg, the hazard ratios (95% confidence intervals) for 120–129, 130–139, and ≥140 mm Hg were 1.33 (1.15 to 1.54), 1.48 (1.27 to 1.72), and 1.82 (1.58 to 2.10), respectively. This association was more evident in analysis with time-updated SBP, where the corresponding hazard ratios (95% confidence intervals) were 1.29 (1.09 to 1.54), 1.75 (1.46 to 2.10), and 2.79 (2.36 to 3.29), respectively. Furthermore, the slopes of eGFR decline were –1.20 (–1.36 to –1.04), –1.77 (–1.97 to –1.57), –2.11 (–2.35 to –1.88), and –2.48 (–2.70 to –2.27) ml/min per 1.73 m 2 per year for respective baseline SBP categories. Additional analyses with diastolic BP also showed similar results. Conclusions In patients with advanced CKD, higher BP levels were associated with a higher risk of CKD progression.
Authors: Cheol Ho Park, Hyung Woo Kim, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Kook-Hwan Oh, Amanda H. Anderson, Wei Yang, Jordana B. Cohen, Mahboob Rahman, Shin-Wook Kang, Seung Hyeok Han, on the behalf of CRIC Study and KNOW-CKD Investigators
Institutions: Yonsei University, Yonsei University Health System, National Health Insurance Service Ilsan Hospital, National Health Insurance Service, Seoul National University, Tulane University, University of Pennsylvania, University Hospitals Cleveland Medical Center, Case Western Reserve University
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1046728144, G1060671437, G1201304535, G145719985, Clinical and Translational Science Institute, American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC), G1815451664, G1822664431, G2375109747, Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study, G2578835210, G2958720900, G2982661698, General Clinical Research Center, G361955624, G3771679604, G4763875946, G4853466809, G5052606370, G5427811063, G571060924, Center for Clinical and Translational Science, G5931204509, G613912715, G6630984261, G742032275, G745724443, G751309980, Institute for Clinical and Translational Research, Institutional Clinical and Translational Science Award, Clinical and Translational Science Collaborative of Cleveland, Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases, Prospective renal insufficiency cohort evaluation: PRICE, Continuation of the University of Illinois Chicago CRIC Clinical Center, Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Hopkins Clinical Center, Tulane Clinical Center for Chronic Renal Insufficiency Cohort Study, Chronic Renal Insufficiency Cohort (CRIC) Study
OpenAlex ID: W4411088479