Work

Brain cell activity detection using optical grating-based surface plasmonic resonance sensor

Year: 2025

Type: article

Abstract: Optical neural recordings are label-free and non-toxic as compared to the other methods. We introduce a compact and reliable membrane activity detection sensor based on surface plasmon resonance (SPR) and optical grating. We utilized a fiber optic port to direct light to the optical grating, allowing us to avoid bulky optical setups. Commercial DVD serves as the optical grating, which is both cost-effective and of high quality. In this sensor, we place mouse hippocampal tissue on the Au-sputtered gratings, and by measuring the reflectance spectrum, we investigate the SPR wavelength shift. The introduction of a high-K + aCSF solution allows us to easily observe the effect of cell depolarization on the SPR wavelength can easily be observed. The proposed sensor achieves a high sensitivity of 628.06 nm/RIU.

Source: Sensing and Bio-Sensing Research

DOI: 10.1016/j.sbsr.2025.100813

Authors: Masoumeh Taghilou, Vahid Ahmadi, Javad Mirnajafi-Zadeh

Institution: Tarbiat Modares University

Language: English

Topic: Plasmonic and Surface Plasmon Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,850

Funder: Iran Nanotechnology Innovation Council