Year: 2025
Type: article
Abstract: Cancer Antigen 15-3 (CA 15-3), a derivative of the MUC1 mucin, epitomizes the intricate interplay between tumor biology and clinical diagnostics. This high-molecular-weight glycoprotein, characterized by aberrant glycosylation, serves as a crucial biomarker in the surveillance of breast cancer. This review delves into the molecular intricacies of CA 15-3, elucidates the methodologies employed in its purification, and highlights its clinical applications. Challenges in assay standardization and the burgeoning role of advanced technologies in refining its diagnostic accuracy are also explored, offering a comprehensive discourse on this pivotal biomarker.
Authors: Shraddha Prabhu Aditi Palav, Rajashree Singh, Kunal Shukla
Institution: Amity University Mumbai
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4411094825