Work

Perspective on Nano-Enabled Photostimulation Biointerfaces

Year: 2025

Type: review

Abstract: Nanostructures enable precise control of biological systems through photoelectrochemical, photothermal, and photocatalytic mechanisms at the cellular and subcellular levels. Here, we discuss three emerging directions in nano-enabled photostimulation biointerfaces. First, artificial intelligence (AI)-driven materials design and high-throughput screening accelerate discovery of optimized nanostructures. Second, innovative device architectures─including robotic assisted and closed-loop platforms─provide real-time monitoring and precise light delivery. Third, expanding applications in tissue engineering and biohybrid systems foster advances in regenerative medicine and neural modulation. By integrating these approaches with nanotechnology, future photostimulation platforms promise highly efficient, customizable, and minimally invasive therapies, offering opportunities in targeted drug delivery, personalized healthcare, and sustainable biomedical technologies.

Source: ACS Nano

DOI: 10.1021/acsnano.5c03602

Authors: Guangqing Yang, Yuze Zheng, Bozhi Tian

Institution: University of Chicago

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, Army Research Office

Awards: Multi-site photostimulation devices using porosity-based semiconductor heterojunctions for cardiac resynchronization therapy, G7077145963