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Pancreatic Plasmacytoma Presenting as Acute Pancreatitis: An Unusual Extramedullary Onset of Multiple Myeloma

Year: 2025

Type: article

Abstract: Multiple myeloma (MM) typically manifests with bone pain, anemia, and hypercalcemia. Extramedullary disease (EMD), particularly pancreatic involvement, is rare. We report a 63-year-old woman presenting with acute pancreatitis secondary to a pancreatic plasmacytoma. Initial symptoms included epigastric pain, elevated lipase (1,389 U/L), and imaging revealing a 12.1 cm pancreatic mass. Biopsy confirmed lambda-restricted plasma cells (CD138+). Bone marrow biopsy showed 15% clonal plasma cells, meeting the diagnostic criteria for MM. EMD in MM signifies aggressive disease and poor prognosis.

Source: Cureus

DOI: 10.7759/cureus.85455

Authors: Bakr Alhayek, Xiaowei Malone, Ariba Khan, Raja Gummalla, Ryan Brink

Institution: AdventHealth Tampa

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411097787