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Assembly of 1,2,3‐Triazole‐Fused Polycyclic Compounds by Palladium‐Catalyzed CH Bond Activation

Year: 2025

Type: article

Abstract: A palladium‐catalyzed protocol for the synthesis of 1,2,3‐triazole‐fused heterocycles, such as 1,4,5,6‐tetrahydrobenzo[c][1,2,3]triazolo[4,5‐e]azepines and 4,6‐dihydro‐1H‐benzo[5,6]oxepino[3,4‐d][1,2,3]triazoles, is reported. The method is versatile, high yielding, and even suitable for domino and one‐pot sequential protocols, combining the copper‐catalyzed reaction of alkynes and organic azides (CuAAC) with palladium‐catalyzed CH bond activation. A plausible reaction mechanism is proposed.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202500459

Authors: Marco Chiarini, Giancarlo Fabrizi, Yuri Gazzilli, Antonella Goggiamani, Antonia Iazzetti, Federico Marrone, Andrea Serafini, Karim Ullah

Institutions: Università Cattolica del Sacro Cuore, University of Teramo, Sapienza University of Rome, Agostino Gemelli University Polyclinic, Istituti di Ricovero e Cura a Carattere Scientifico, KU Leuven

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W4411101451

FWCI:

Cites: 31

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Related to: 10