Cytomegalovirus infection in infants with biliary atresia in China: a multi-center investigation study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background and objectives: Biliary atresia (BA) with concurrent cytomegalovirus (CMV) is a distinct subtype that is linked to a poorer prognosis. Currently, there are no standardized criteria for the diagnosis or antiviral treatment (AVT) of this condition. It has a high prevalence in China. The aim was to investigate the infection, diagnosis and treatment of CMV infection in infants with BA through a multicenter questionnaire survey conducted in China. Methods: A multicenter investigation was performed through online questionnaire survey. It investigated the diagnosis and treatment of infants with CMV-infected BA in tertiary-level pediatric centers from January 1st, 2018, to January 1st, 2020. The centers were categorized into low and high-volume groups based on number of infants with BA (≤50 or >50) and were also grouped geographically into south and north groups. Afterward, 100 cases were randomly selected from these infants for a retrospective analysis. Results: A total of 22 questionnaires were collected, and 20 were included in the analysis. The questionnaire survey encompassed 1,276 infants with type III BA. 31.3% of the infants of BA had CMV detected. According to the survey results, a large proportion of centers preferred using CMV-DNA (75.0%) and CMV-IgM (95.0%) as their preferred methods for CMV detection. In the high-volume group, more centers opted for CMV-DNA detection (100.0% vs. 66.7%) and administered AVT (87.5%). In the retrospective analysis of 100 infants with BA, 39 were found to be CMV-positive and among these, 74.4% received AVT. Conclusion: Among the 1,276 infants with BA in this cohort, 31.3% (399 cases) had concomitant CMV infection, representing a decrease compared to previous data. CMV-IgM played a crucial role in the detection of the infection. The retrospective analysis indicated that AVT had a beneficial impact on the prognosis of infants with BA who were infected with CMV.
Source: Frontiers in Pediatrics
Authors: Yilin Zhao, Xiaodan Xu, Yu Meng, Chonggao Zhou, Baijun Zheng, Xianwei Zhang, Bin Wang, Xufei Duan, Yuanmei Liu, Jiexiong Feng, Jie Zhu, Zhibo Zhang, Yajun Chen, Zhibao Lv, Yuanjun Hu, Hongxia Ren, Liuming Huang, Yingchao Li, Liang Ge, Haochuan Zhang, Xiang Liu, Wanfu Li, Qingbo Cui, Jianghua Zhan
Institutions: Tianjin University, Tianjin Children's Hospital, Tianjin Medical University, Hunan Children's Hospital, Second Affiliated Hospital of Xi'an Jiaotong University, Zhengzhou Children's Hospital, Shenzhen Children's Hospital, Wuhan Children's Hospital, Zunyi Medical University, Tongji Hospital, Huazhong University of Science and Technology, Soochow University, Children's Hospital of Suzhou University, Sheng Jing Hospital, China Medical University, Capital Medical University, Beijing Children’s Hospital, Shanghai Jiao Tong University, Shanghai Children's Hospital, Shanxi Provincial Children's Hospital, Chinese PLA General Hospital, Hebei Medical University, Second Hospital of Hebei Medical University, Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Anhui Provincial Children's Hospital, First Affiliated Hospital of Xinjiang Medical University, Harbin Medical University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4411107538