Work

Case report of hypercalcemia-related kidney complications after discontinuation of denosumab

Year: 2025

Type: article

Abstract: Background: The use of the osteoclastogenesis inhibitor denosumab is increasing in pediatrics, especially in the treatment of giant cell tumor or granuloma of bone or jaw, aneurysmal bone cyst, and other rare bone disorders. Particularly in pediatric patients, adverse kidney effects-such as acute kidney injury (AKI), hypertension, and nephrocalcinosis-are a significant concern that has received little attention. Case-diagnosis/treatment: In this report, we present three children who developed hypercalcemia-related AKI six months after discontinuation of denosumab treatment. Treatment of the hypercalcemia consisted of hyperhydration, and administration of furosemide, denosumab or bisphosphonate. Conclusions: Clinicians should be aware of the side effects of denosumab for at least seven months after discontinuation of denosumab. Early diagnosis and prompt management of hypercalcemia will result in recovery of AKI, however long-term consequences cannot be ruled out.

Source: Frontiers in Pediatrics

DOI: 10.3389/fped.2025.1583240

Authors: Gerrit van den Berg, Marc R. Lilien, Rutger R. G. Knops, Robert J. J. van Es, Atty T. H. van Dijk, Mandy G. Keijzer-Veen

Institutions: University Medical Center Utrecht, Wilhelmina Children's Hospital, Princess Máxima Center, Utrecht University

Language: English

Topic: Bone health and treatments

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801