Work

Epigenetic regulation of intracellular branched-chain amino acid homeostasis maintains a normal lifespan

Year: 2025

Type: article

Abstract: restored icBCAA balance and partially rescued lifespan defects in H3K4 or H3K121 mutants. Additionally, H3K4 and H3K121 mutations affected lifespan regulation through TORC1 signaling. Our findings suggest that the epigenetic control of BCAA metabolism, specifically through the modification of histone residues, contributes to maintaining metabolic homeostasis and replicative lifespan.

Source: iScience

DOI: 10.1016/j.isci.2025.112846

Authors: Sejung Park, Yan Liu, Suji Lim, Hong-Yeoul Ryu, Seong Hoon Ahn

Institutions: Hanyang University, Kyungpook National University

Language: English

Topic: Genetics, Aging, and Longevity in Model Organisms

Subfield: Aging

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240