Cellular heterogeneity and patterning strategies as revealed by upper respiratory epithelium single cell atlas
Year: 2025
Type: article
Abstract: + submucosal glands. Stratified squamous pharyngolaryngeal zones displayed extensive and region-specific Keratin codes. Within the pseudostratified tracheobronchial epithelium, diverse luminal cells, including multiple varieties of club cells, exhibit marker-expression gradients along the proximal-distal axes. Lastly, analysis of the submucosal gland epithelium -which contains various cell types, including distinctive myoepithelial cells- revealed extensive diversity both among and within its cellular populations. This spatially resolved transcriptomic atlas elucidates how epithelial identity varies along the upper respiratory axes and will guide investigations into cellular dynamics in health and disease.
Source: iScience
Authors: Alexander G. Foote, Xin Sun
Institution: University of California San Diego
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,240
Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Neurological Disorders and Stroke, National Center for Complementary and Integrative Health, NHLBI Division of Intramural Research
OpenAlex ID: W4411111683