Work

Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review

Year: 2025

Type: article

Abstract: ABSTRACT Hepatitis B virus (HBV) is a significant global health concern, characterized by its potential to cause acute and chronic liver diseases. Despite the availability of effective vaccines and treatments, substantial gaps remain in the management of chronic infections, particularly in regions like China, where millions are affected. This review delves into the synthesis of clinical anti-HBV drugs, including lamivudine, adefovir, tenofovir, entecavir, and telbivudine, highlighting various synthetic strategies. By emphasizing efficient synthetic routes suitable for large-scale production, this review contributes valuable insights for enhancing treatment accessibility and improving patient outcomes in hepatitis B management.

Source: Green Synthesis and Catalysis

DOI: 10.1016/j.gresc.2025.06.001

Authors: Houzong Yao, Xianjing Zheng, Minjie Liu, Yuelun Xu, Ping Xu, Fen-Er Chen

Institutions: Jiangxi Normal University, Fudan University, Fuzhou University

Language: English

Topic: Hepatitis B Virus Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, Natural Science Foundation of Jiangxi Province, Jiangxi Provincial Department of Science and Technology