Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: The effects of vitamin D on the human body have been the subject of numerous studies.Its beneficial effects on the immune system are promising.The aim of this study was to investigate the correlation between serum vitamin D concentration and cell death evaluated by the quantification of Fas apoptotic factor in healthy patients.Methods: All patients included in the study were prospectively selected among individuals who attended a medical consultation between 2023 and 2024 and who needed to undergo routine laboratory tests on that occasion, including vitamin D levels.The results of serum samples from 77 healthy individuals, collected from the electronic medical records, were analysed.The concentrations of vitamin D and Fas protein measured by electrochemiluminescence and fluorescence methods, respectively, were compared.Results: Our study reviewed 77 patient records from our archives that met the inclusion criteria.Age ranged from 18 to 95 years and there were 43 females and 34 males.We found a statistically significant and strong relationship between vitamin D and Fas protein levels (p=0.016).There were no significant differences in vitamin D levels according to age or sex. Conclusion:Our results show an important correlation between vitamin D levels and Fas apoptotic factor in serum from healthy subjects.Factors such as age or sex did not obtain statistical significance.Future studies involving larger samples conducted at various centers that monitor and adjust blood vitamin D levels in each particular case are essential to identify approaches to improving and strengthening the immune system of the world population.
Source: Annals of Case Reports
Author: Jose Augusto Camargo
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411112338