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Silent Threats to the Liver: Acute Hepatotoxicity Attributed to Selective Androgen Receptor Modulators (SARMs)

Year: 2025

Type: article

Abstract: Selective androgen receptor modulators (SARMs) have garnered significant attention in recent years due to their potential to improve muscle mass and athletic performance with reduced androgenic side effects compared to traditional anabolic steroids. However, despite their growing popularity, there is increasing evidence linking SARMs to acute liver injury, raising concerns regarding their safety profile. SARMs can disrupt normal liver function through various pathways, including oxidative stress, alterations in lipid metabolism, and direct hepatocellular toxicity. This article explores the association between SARMs and acute liver injury, examining the mechanisms of hepatotoxicity, clinical manifestations, and potential therapeutic approaches. The findings underscore the need for further research and regulatory oversight in using SARMs, particularly in non-medical and performance-enhancing contexts.

Source: Cureus

DOI: 10.7759/cureus.85500

Authors: Bola Habeb, Otto Valdes, Sandy Khair, Erica S Thomson

Institutions: University of Florida, Sacred Heart Hospital, Sacred Heart Health System, Cairo University

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411112345