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Apixaban- and Rivaroxaban-Associated Bleeding: A Retrospective Analysis Using the FDA Adverse Event Reporting System

Year: 2025

Type: article

Abstract: Apixaban and rivaroxaban are two agents commonly used for anticoagulation to treat and prevent blood clots and strokes in individuals with atrial fibrillation (AF). We extracted data from the FDA Adverse Event Reporting System (FAERS) database to evaluate the reporting frequency of ocular, cerebral, gastrointestinal (GI), rectal, and renal hemorrhage, epistaxis, and hemoptysis related to apixaban and rivaroxaban from January 2012 to March 2024. We calculated relative odds ratios (RORs) with 95% confidence intervals (CIs) to compare the hemorrhagic risk profiles of the two agents. There was no statistical significance in reported cases of ocular hemorrhage in apixaban versus rivaroxaban. Based on RORs, rivaroxaban overall has a significantly higher risk of bleeding in multiple organ systems - especially cerebral, GI, rectal, and renal hemorrhage, as well as epistaxis and hemoptysis. Apixaban may be a safer option for individuals at risk for, or with a history of, these complications.

Source: Cureus

DOI: 10.7759/cureus.85509

Authors: Ilana K Logvinsky, Christian Sanchez, Claudiu Ciuciureanu, Eric Wu, Osama El Aryan, Maja Delibasic

Institutions: Florida State University, Nova Southeastern University

Language: English

Topic: Atrial Fibrillation Management and Outcomes

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411114018