Year: 2025
Type: article
Abstract: Background: According to the World Health Organisation (WHO), malaria remains a leading burden of illness in low- and middle-income countries, accounting for 94% of cases and 95% of deaths in 2022. As the 2030 Global Goals approach, preventive and chemotherapeutic interventions are necessary to curb malaria virulence, making it crucial to review novel approaches to combat this disease. Objective: This paper aims to review the top two vaccines for malaria prevention, evaluate their efficacy, and examine potential challenges to their deployment in low- and middle-income countries. Methods: A comprehensive review was conducted focusing on the leading malaria prevention vaccines, their effectiveness profiles, and the barriers to implementation in resource-limited settings. Results: While vaccine usage demonstrates significant potential for malaria prevention, considerable challenges exist in vaccine development and large-scale production in low- and middle-income countries due to limited funding resources. Additionally, misconceptions about vaccines present barriers to acceptance and uptake. Conclusions: Although malaria vaccines offer promising preventive potential, successful deployment in low- and middle-income countries requires addressing funding limitations for development and production, as well as implementing public enlightenment programs and awareness-raising sessions to combat vaccine misconceptions before deployment.
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411116267