Work

Cytoplasmic physicochemical factors drive malignant transformation by adapting bioenergetic settings

Year: 2025

Type: article

Abstract: While significant insights have been gained by a study of cancer genetics, the roles of the cytoplasm in regulating chemical processes during the transformation to malignancy are often less appreciated. The cytoplasm functions as a two-phase system consisting of an elastic solid phase (the cytomatrix) and a viscous liquid phase (the cytosol). This finding has led to the development of a tumor progression model based on a two-phase system that connects genetic alterations with the physicochemical processes necessary for sustaining and facilitating malignant growth. Here, we show that the energy required for tumor growth is, in part, required for the cytomatrix activity, which accelerates chemical reactions. The ability to regulate cytomatrix motor proteins provides a mechanism to control whether a genetic mutation is able to induce the energy needed for cancer to develop and offers innovative strategies for cancer treatment.

Source: Biochemistry and Biophysics Reports

DOI: 10.1016/j.bbrep.2025.102079

Author: Tattym E. Shaiken

Institutions: Baylor College of Medicine, University of Houston

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,700