Year: 2025
Type: article
Study design: Case Report
Abstract: Diffuse idiopathic skeletal hyperostosis (DISH), a common cause of thoracic backache, may be caused by unregulated growth factor activity by increasing enthesis and bony growth. Excess growth factors can cause acromegaly. We describe the case of a patient presenting with chronic thoracic axial back pain for several decades and features of acromegaly on history and physical exam. Single photon emission computed tomography (SPECT) CT was obtained to identify the pain generator and detected increased metabolic activity in the anterior column suggestive of DISH. Subsequent laboratory testing revealed acromegaly. Follow-up imaging identified a growth hormone (GH)-secreting pituitary macroadenoma with local invasion. To the best of our knowledge, this is the first time the finding of DISH has hinted at the possibility of acromegaly, and may illustrate the need for added vigilance for acromegaly in patients with DISH.
Source: Cureus
DOI: 10.7759/cureus.85533
Authors: Ammar Siddiqui, Melissa Chao, Michael Rahimi, Alla Spivak, Michael Weinberger
Institutions: New York Medical College, Columbia University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411117138