Serum GP73, Nrf2, CHE in early pregnancy-related liver injury detection via RCS model
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: This study assessed serum GP73, Nrf2, and CHE levels in pregnancy-associated liver injury and explored their nonlinear risk relationships using restricted cubic spline (RCS) models to establish diagnostic thresholds for early screening. METHODS: Conducted from December 2022 to December 2024, 105 pregnant women with liver injury (research group) and 187 healthy controls were retrospectively analyzed. Multivariate logistic regression, ROC curves, RCS models, and decision curve analysis (DCA) evaluated associations, predictive efficacy, dose-response relationships, and clinical utility of these biomarkers. RESULTS: < 0.001), and DCA confirmed clinical significance (net benefit > 0) for individual and combined biomarkers, with the panel showing the highest utility. CONCLUSION: GP73, Nrf2, and CHE demonstrated nonlinear associations with pregnancy-related liver injury, particularly GP73. Combined measurement enhances clinical value for early prediction.
Source: Biomarkers in Medicine
Authors: Deng Huang, Yanjun Hu, Biwen Dong, Zhi Zheng, Hai Wang, Tingting Liao, Wenhan Wang, Xianjue Zheng, Zitong Xu, Shuqi Xia, Xiaoqing Li, Congcong Sun, Hongping Zhang, Jiayong Zheng
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G5000333385
OpenAlex ID: W4411123185